The singer-songwriter, who is recovering from throat surgery which forced her to cancel a string of UK concerts last month, will take on the likes of Lady Gaga and Katy Perry in categories including song, record and album of the year.
English folk rock band Mumford and Sons are also flying the flag for British music, receiving four nominations including best song and record, while the late Amy Winehouse could be honoured with a posthumous Grammy after being shortlisted in the best pop duo/group performance for her collaboration with Tony Bennett on the track Body And Soul.
The nominations were announced at a ceremony broadcast live from the Nokia Theatre in Los Angeles earlier today.
American rapper turned actor LL Cool J hosted the star studded nominations show which included performances from Lady Gaga, Rihanna and Usher.
Adele, who was diagnosed with a vocal cord haemorrhage that threatened to wreck her voice, was nominated in the best song and record categories for her chart-topping anthem Rolling in the Deep and is in the running for best album with her multi-platinum offering 21.
The Someone Like You singer recently told fans her throat operation had been a success and she was "on the mend". It has been reported that she is to make her comeback performance at the X Factor final later this month.
Kanye West, who has 14 Grammys to his name, led the nominations with seven nods, while Foo Fighters and Bruno Mars joined Adele with six.
The winners will be announced at the 54th annual awards ceremony in Los Angeles in February.